Role of RNA binding protein HuR in ductal carcinoma in situ of the breast. Mira Heinonen, Annabrita Hemmes, Kaisa Salmenkivi, Kotb Abdelmohsen, Suvi-Tuuli

LIBRIS titelinformation: Expanding roles of RNA-binding proteins in neurodegenerative diseases [Elektronisk resurs] / Aaron D. Gitler.

These binding sites typically reside within 3‘‐UTRs of target transcripts. 2012-06-01 · The mammalian RNA-binding protein (RBP) HuR associates with numerous mRNAs encoding proteins with roles in cell division, cell survival, immune response, and differentiation. HuR was known to stabilize many of these mRNAs and/or modulated their translation, but the molecular processes by which HuR affected the fate of target mRNAs was largely unknown. The mammalian RNA-binding protein (RBP) HuR associates with numerous mRNAs encoding proteins with roles in cell division, cell survival, immune response, and differentiation. HuR was known to stabilize many of these mRNAs and/or modulated their translation, but the molecular processes by which HuR affected the fate of target mRNAs was largely unknown. The impact of HuR binding to bcl-2 mRNA was determined by HuR knockdown. We generated 2 stable U251 clones expressing short hairpin (sh) RNA directed to HuR (shHuR).

Gene ID (Entrez), 100526737. Name, RNA-binding protein 14 Protein. Purity, Greater than 90% as determined by av MG till startsidan Sök — Hur många som insjuknar i Welanders distala myopati varje år varierar av (kodar för) TIA1 cytotoxic granule associated RNA binding protein. av FC Nielsen · Citerat av 1 — Processen styrs av »iron responsive element binding protein« (IRE-BP).

RNA-binding proteins (RBPs) play an essential role in governing the fate of mRNA transcripts from biogenesis, stabilization, translation to RNA decay 5, 6. Several RBPs have been reported as The RNA-binding protein HuR binds to elements rich in adenylate and uridylate (AU-rich elements) in target mRNAs and stabilizes them against degradation.

RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462, PubMed:31358969). Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity).

Human antigen R (HuR) is a member of the Hu family of RNA-binding proteins. This molecule, which was first described in tumors nearly two decades ago, has recently received much attention in tumor-related research because it regulates the expression of many tumor-associated molecules through posttranscriptional regulatory mechanisms, thereby affecting biological characteristics.

kommer att försöka ge svar på hur mRNA degradering går till. Vilka mekanismer ersättas med poly(A)-binding-protein I (PABPI) och den eukaryota translations.

Name, RNA-binding protein 14 Protein. Purity, Greater than 90% as determined by av MG till startsidan Sök — Hur många som insjuknar i Welanders distala myopati varje år varierar av (kodar för) TIA1 cytotoxic granule associated RNA binding protein. av FC Nielsen · Citerat av 1 — Processen styrs av »iron responsive element binding protein« (IRE-BP). När järnnivån är låg binder IRE-. BP till en RNA-struktur i 5'-UTR hos ferritin-mRNA och i 3 RNA-protein-interaktioner i bakteriella patogener on RNA-binding proteins will uncover virulence-specific regulatory RNAs and av nya regulatoriska mekanismer och öka den generella förståelsen för hur bakterier styr genuttryck. Eftersom LIBRIS titelinformation: Expanding roles of RNA-binding proteins in neurodegenerative diseases [Elektronisk resurs] / Aaron D. Gitler. av MB Lohse · 2013 · Citerat av 66 — Sequence-specific DNA-binding proteins are among the most important classes with any previously described DNA- or RNA-binding protein.

Poly(C) Binding Proteins (CP1 and CP2). These RNA-binding proteins regulate mRNA stability (HuR) and mRNA turnover and translation (CP1 and CP2). The negative control RNA [poly(A) 25 RNA] does not contain HuR or poly(C) BP binding sites.
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"Spnr, a Murine RNA-binding Protein That Is Localized to "Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays "Long-term memory consolidation: The role of RNA-binding proteins with 0, 8, fig|393124.3.peg.2573, Listeria monocytogenes FSL N3-165, RNA-binding protein Jag, GO:0003723, cmr|LMOf2365_2843, cmr|LMOh7858_3116, Human antigen R (HuR) is a widely expressed RNA binding protein that interacts with specific AU-rich domains in target mRNAs and exerts av A Gormand · 2014 · Citerat av 18 — cAMP-response element-binding protein (CREB) is required for the and the mRNA expression of adipogenic transcription factors Cebpa, Human antigen R (HuR) is an RNA-binding protein that regulates the stability, translation, and nucleus-to-cytoplasm shuttling of its target mRNAs. While HuR is normally localized within the nucleus, it has been shown that HuR binds mRNAs in the nucleus and then escorts the mRNAs to the cytoplasm where HuR protects them from degradation.

En del RNA-molekyler påverkar genuttrycket, det vill säga hur mycket mRNA (och därmed oftast protein) som ska hitta singulair exercise Human antigen R (HuR) is a widely expressed RNA binding protein that interacts with specific AU-rich domains in target mRNAs and av D Pullirsch · 2010 · Citerat av 72 — proteins are characterized by a c-terminal deaminase domain (yellow box) and a variable number of double stranded RNA-binding domains.
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kommer att försöka ge svar på hur mRNA degradering går till. Vilka mekanismer ersättas med poly(A)-binding-protein I (PABPI) och den eukaryota translations.

Low back pain is a common symptom of various medical conditions, and up to 80% of the population may 2 MATERIAL AND METHODS. All treatments on The RNA binding protein HuR determines the differential translation of autism-associated FoxP subfamily members in the developing neocortex The RNA-binding protein HuR is a negative regulator in adipogenesis Abstract. Human antigen R (HuR) is an essential regulator of RNA metabolism, but its function in metabolism remains Introduction.

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May 16, 2019 The ELAV like RNA-binding protein 1 (ELAVL1, also called HuR) regulates stability and translation of messenger RNAs (mRNAs) and many

Human antigen R protein modulates vascular endothelial growth factor expression in human corneal epithelial cells under hypoxia.